A matter of life or death: modulation of neutrophil apoptosis and complement activation by Francisella tularensis
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Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil Apoptosis.
Tularemia is a disease characterized by profound neutrophil accumulation and tissue destruction. The causative organism, Francisella tularensis, is a facultative intracellular bacterium that replicates in neutrophil cytosol, inhibits caspase activation and profoundly prolongs cell lifespan. Here, we identify unique features of this infection and provide fundamental insight into the mechanisms o...
متن کاملExploitation of Host Cell Biology and Evasion of Immunity by Francisella Tularensis
Francisella tularensis is an intracellular bacterium that infects humans and many small mammals. During infection, F. tularensis replicates predominantly in macrophages but also proliferate in other cell types. Entry into host cells is mediate by various receptors. Complement-opsonized F. tularensis enters into macrophages by looping phagocytosis. Uptake is mediated in part by Syk, which may ac...
متن کاملImportance of PdpC , IglC , IglI , and IglG for modulation of a host cell death 2 pathway induced by Francisella tularensis LVS 3 4 5 6 7 8
1 Importance of PdpC, IglC, IglI, and IglG for modulation of a host cell death 2 pathway induced by Francisella tularensis LVS 3 4 5 6 7 8 Marie Lindgren, Kjell Eneslätt, Jeanette E. Bröms, and Anders Sjöstedt* 9 10 Department of Clinical Microbiology, Clinical Bacteriology and Laboratory for Molecular 11 Infection Medicine Sweden (MIMS), Umeå University, SE-901 85 Umeå, Sweden 12 13 Running ti...
متن کاملNatural IgM mediates complement-dependent uptake of Francisella tularensis by human neutrophils via complement receptors 1 and 3 in nonimmune serum.
A fundamental step in the life cycle of Francisella tularensis is bacterial entry into host cells. F. tularensis activates complement, and recent data suggest that the classical pathway is required for complement factor C3 deposition on the bacterial surface. Nevertheless, C3 deposition is inefficient and neither the specific serum components necessary for classical pathway activation by F. tul...
متن کاملBacterial lipoproteins and other factors released by Francisella tularensis modulate human neutrophil lifespan: Effects of a TLR1 SNP on apoptosis inhibition
Francisella tularensis infects several cell types including neutrophils, and aberrant neutrophil accumulation contributes to tissue destruction during tularaemia. We demonstrated previously that F. tularensis strains Schu S4 and live vaccine strain markedly delay human neutrophil apoptosis and thereby prolong cell lifespan, but the bacterial factors that mediate this aspect of virulence are und...
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تاریخ انتشار 2016